Effect of zinc on leucocyte sodium transport in vitro.
نویسندگان
چکیده
1. In a preparation of human leucocytes maintained in tissue culture fluid, increasing the extracellular zinc concentration leads to a significant increase in both ouabain-sensitive sodium efflux and in sodium influx. 2. Cell water and sodium content do not alter significantly with increasing extracellular zinc concentration. 3. A small increase in the ouabain-insensitive sodium efflux can be demonstrated when the external zinc concentration is raised from 0.75 mumol/l to 90 mumol/l.
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may have been zinc deficient, though none had features attributable to zinc depletion. Again, these results might be explained by a diminished amount of zinc binder in the leucocytes. A cellular effect of a low plasma concentration of zinc has recently been found by Patrick and his colleagues,10 who showed that the zinc is an important controller of the sodium pump in leucocytes. More recently ...
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ورودعنوان ژورنال:
- Clinical science and molecular medicine
دوره 54 5 شماره
صفحات -
تاریخ انتشار 1978